100 Basopenia during the symptoms of chronic spontaneous urticaria reflects migration of basophils from the peripheral blood to the skin

In chronic spontaneous urticaria (CSU), a decrease in the number of basophils peripheral blood (PB), or basopenia, is observed. However, its mechanism has not been clarified. Therefore, we examined whether basopenia CSU reflects infiltration inflamed skin. First, compared basophil counts PB before and after treatment. The increased following improvement symptom 15 out 17 patients treated with omalizumab 13 antihistamines. Immunostaining showed lesions, but since most these were already taking oral steroids, did think it appropriate to examine relationship between numbers tissue PB. Next, tested contact hypersensitivity model single application oxazolone (OX), which known infiltrate into A was observed 1 day challenge. 2 days challenge, no Since an increase bone marrow (BM) at this time, hypothesized that recovery reflected supply new from BM. Then, transplanted cultured expressing GFP challenged OX. results GFP-positive decreased challenge due tissue, remained low even Thus, observation basopenira OX may be related differences ability humans mice mobilize Our suggest migration circulating skin involved CSU.